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This list was produced jointly by Professor G Elder, Department of Medical Biochemistry, University Hospital of Wales and staff of the Welsh Medicines Information Centre (WMIC).  It is based on the best information available to us at the time of compilation.  
Inclusion of a drug does not guarantee that it will be safe in all circumstances.


Knowledge in the field of drug use in porphyria is continually increasing and therefore will change with time. 
 
If you wish to confirm the safety of any drug please contact the 
    Welsh Medicines Information Centre      
   
Tel:  029 2074 3877       
   
Fax:  029 2074 3879       
   
email:   fiona.woods@cardiffandvale.wales.nhs.uk                           
(also see the Alphabetical List)

Drugs that are considered safe in the acute porphyrias:   

Categorised List   

Anti-emetics

Antivirals/Antifungals

Analgesics (cont.)

Miscellaneous (cont.)

Cyclizine

Aciclovir

Co-dydramol

Flumazenil

Domperidone

Amphotericin

Codeine phosphate

Fructose

Meclozine

Famciclovir

Dextromethorphan

FSH

Prochlorperazine

Flucytosine

Dextromoramide

Glipizide

Promazine

Ganciclovir

Dextropropoxyphene

Glucagon

Valaciclovir

Diamorphine

Glucose

Antihistamines

Zalcitabine

Diflunisal

Glycopyrronium

Chlorpheniramine

Dihydrocodeine

Gonadorelin

Diphenhydramine

Cardiovascular agents

Fenbufen

Goserelin

Ketotifen

Amiloride

Fentanyl

Hetastarch

Loratadine

Beta blockers

Flurbiprofen

Insulin

Promethazine

Bumetanide

Ibuprofen

Iron

Trimeprazine

Chlorothiazide

Indomethacin

Ispaghula

Cyclopenthiazide

Ketoprofen

Lactulose

Antibacterial agents

Dalteparin

Methadone

Leuprorelin

Aminoglycosides

Diazoxide

Morphine

Levothyroxine

Co-amoxiclav

Digoxin

Nalbuphine

LHRH

Ethambutol

Dipyridamole

Naproxen

Lithium

Flucloxacillin  1

Dobutamine

Paracetamol

Loperamide

Penicillins

Dopamine

Pethidine

Lorazepam

Pentamidine

Enalapril

Sulindac

Magnesium sulphate

Sodium fusidate

Enoxaparin

Tiaprofenic acid

Melphalan

Streptomycin

Glyceryl trinitrate

Mesalazine

Vancomycin

Guanethidine

Corticosteroids + other

Metformin

Heparin

immunosuppressants

Methotrimeprazine

Lipid lowering agents

Hydrochlorothiazide

Beclomethasone

Methylphenidate

Bezafibrate

Lisinopril  4

Ciclosporin 5

Midazolam

Cholestyramine

Naftidrofuryl

Corticosteroids

Naloxone

Colestipol

Prazosin

Hydrocortisone

Octreotide

Fenofibrate

Procainamide

Methylprednisolone

Omeprazole

Gemfibrozil

Quinidine

Prednisolone

Oxybuprocaine

Streptokinase

Oxytocin

Local Anaesthetics

Tinzaparin

Miscellaneous

Paraldehyde

Amethocaine

Triamterene

Acetazolamide

Penicillamine

Bupivacaine

Urokinase

Acetylcysteine

Phytomenadione

Lignocaine  2

Allopurinol

Primaquine

Prilocaine

Anticonvulsants

Alpha tocopheryl

Propantheline

Procaine

Clobazam

Aluminium salts

Propylthiouracil

Tetracaine

Clonazepam

Amantadine

Proxymetacaine

Gabapentin

Ascorbic acid

Pseudoephedrine

Immunisations

Sodium valproate  3

Azathioprine

Pyridoxine

Immunoglobulins

Valproate  3

Bismuth

Pyrimethamine

Vaccines

Vigabatrin

Bromazepam

Quinine

Buserelin

Resorcinol

Antidepressants

Drugs used in anaesthesia

Calcitonin

Salbutamol

Amitriptyline

Adrenaline

Calcium carbonate

Senna

Fluoxetine

Atropine

Carbimazole

Sodium acid phos

Lofepramine

Cyclopropane

Chloral hydrate

Sodium bicarbonate

Mianserin

Epinephrine

Cisplatin

Sorbitol

Ether

Clomiphene

Sucralfate

Antipsychotics

Isoflurane

Colchicine

Temazepam

Chlorpromazine

Neostigmine

Corticotrophin

Thiamine

Fluphenazine

Nitrous oxide

Danthron

Thyroxine

Haloperidol

Pancuronium

Desferrioxamine

Tranexamic acid

Pipothiazine

Phentolamine

Dextran

Vitamins

Trifluoperazine

Propofol

Dextrose

Warfarin

Suxamethonium

Dicyclomine

Zinc preparations

Malaria Prophylaxis

Dimercaprol

Chloroquine

Analgesics

Dimethicone

Mefloquine

Alfentanil

Diphenoxylate

Proguanil

Aspirin

Distigmine

Buprenorphine

Doxorubicin

Co-codamol

Droperidol

  1. Large intravenous doses may be associated with acute attacks (unproven as causative agent)
  2. Intravenous doses should be avoided
  3. Sodium valproate should only be used where other safe antiepileptics are ineffective or inappropriate
  4. Safety under review, contact WMIC
  5. Contact WMIC for information regarding other immunosuppressants

This page last updated by Central Sydney Laboratory Service on 17 October 2001.
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